2023
Eckel-Mahan K. Energy intake at the intersection of the clock and ageing. Nat Rev Endocrinol. 2023 Feb;19(2):72-73. doi: 10.1038/s41574-022-00791-3 PMID: 36536066 Free PMC article.
Van Drunen R, Eckel-Mahan K. Circadian rhythms as modulators of brain health during development and throughout aging. Front Neural Circuits. 2023 Jan 19;16:1059229. doi: 10.3389/fncir.2022.1059229. eCollection 2022. PMID: 36741032 Free PMC article. Review.
Eckel-Mahan K. The importance of "when" in calorie restriction-induced lifespan extension. J Cardiovasc Aging. 2023;3(1):5. doi: 10.20517/jca.2022.40. Epub 2023 Jan 1. PMID: 36544807
Younes M, Zhang L, Fekry B, Eckel-Mahan K. Expression of p-STAT3 and c-Myc correlates with P2-HNF4α expression in nonalcoholic fatty liver disease (NAFLD). Oncotarget. 2022 Dec 6;13:1308-1313. doi: 10.18632/oncotarget.28324. PMID: 36473131 Free PMC article.
Li G, Li X, Mahmud I, Ysaguirre J, Fekry B, Wang S, Wei B, Eckel-Mahan KL, Lorenzi PL, Lehner R, Sun K. Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy. JCI Insight. 2023 Jan 24;8(2):e163624. doi: 10.1172/jci.insight.163624. PMID: 36472914 Free PMC article.
2022
Eckel-Mahan K. Temporal and spatial metabolite dynamics impart control in adipogenesis. J Cell Biol. 2022 Dec 5;221(12):e202210021. doi: 10.1083/jcb.202210021. Epub 2022 Nov 21. PMID: 36409212
Fekry B, Ribas-Latre A, Drunen RV, Santos RB, Shivshankar S, Dai Y, Zhao Z, Yoo SH, Chen Z, Sun K, Sladek FM, Younes M, Eckel-Mahan K. Hepatic circadian and differentiation factors control liver susceptibility for fatty liver disease and tumorigenesis. FASEB J. 2022 Sep;36(9):e22482. doi: 10.1096/fj.202101398R.
Thomas SS, Wu J, Davogustto G, Holliday MW, Eckel-Mahan K, Verzola D, Garibotto G, Hu Z, Mitch WE, Taegtmeyer H. SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease. Circ Res. 2022 Jul 22;131(3):207-221. doi: 10.1161/CIRCRES AHA.121.320546. Epub 2022 Jun 20.
Ribas-Latre A, Eckel-Mahan K. Nutrients and the Circadian Clock: A Partnership Controlling Adipose Tissue Function and Health. Nutrients. 2022 May 16;14(10):2084. doi: 10.3390/nu14102084.
Fekry B, Eckel-Mahan K. The circadian clock and cancer: links between circadian disruption and disease Pathology. J Biochem. 2022 May 11;171(5):477-486. doi: 10.1093/jb/mvac017. PMID: 35191986 Review.
Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, Smith JA, Ono K, Kim JA, Eckel-Mahan K, Zhou X, Lee HK, Yoo JY, Yoo SH, Chen Z. ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell Death Dis. 2022 Apr 19;13(4):374. doi: 10.1038/s41419-022-04826-5. PMID: 35440077 Free PMC article.
Li G, Li X, Yang L, Wang S, Dai Y, Fekry B, Veillon L, Tan L, Berdeaux R, Eckel-Mahan K, Lorenzi PL, Zhao Z, Lehner R, Sun K. Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice. Life Sci Alliance. 2022 Apr 22;5(8):e202101209. doi: 10.26508/lsa.202101209. Print 2022 Aug. PMID: 35459739 Free PMC article.
2021
Ribas-Latre A, Santos RB, Fekry B, Tamim YM, Shivshankar S, Mohamed AMT, Baumgartner C, Kwok C, Gebhardt C, Rivera A, Gao Z, Sun K, Heiker JT, Snyder BE, Kolonin MG, Eckel-Mahan KL. Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue. Nat Commun. 2021 Jun 9;12(1):3482. doi: 10.1038/s41467-021-23770-0.
Davogustto GE, Salazar RL, Vasquez HG, Karlstaedt A, Dillon WP, Guthrie PH, Martin JR, Vitrac H, De La Guardia G, Vela D, Ribas-Latre A, Baumgartner C, Eckel-Mahan K, Taegtmeyer H. Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. J Mol Cell Cardiol. 2021 Jun 1;158:115-127. doi: 10.1016/j.yjmcc.2021.05.016. Online ahead of print.
Circadian Rhythms of the Hypothalamus: From Function to Physiology. Van Drunen R and Eckel-Mahan KL. Clocks and Sleep. 2021 Jan;3(1):189-226. doi: 10.3390/clockssleep3010012
Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences. Eckel-Mahan K, Ribas Latre A, Kolonin MG. Cells. 2020 Apr 2;9(4):863. doi: 10.3390/cells9040863. PMID: 32252348
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease. Gao Z, Daquinag AC, Fussell C, Zhao Z, Dai Y, Rivera A, Snyder BE, Eckel-Mahan KL, Kolonin MG. Nat Metab. 2020 Dec;2(12):1482-1497. doi: 10.1038/s42255-020-00320-4. Epub 2020 Dec 14. PMID: 33324010
Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge. Tognini P, Samad M, Kinouchi K, Liu Y, Helbling JC, Moisan MP, Eckel-Mahan KL, Baldi P, Sassone-Corsi P. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29904-29913. doi: 10.1073/pnas.2016589117. Epub 2020 Nov 10. PMID: 33172990
Paolo Sassone-Corsi. Masri, M, Nakahata, Y, Eckel-Mahan KL. Journal of Biological Rhythms U S A. 2020 Oct. 7 https://doi.org/10.1177/0748730420962657
Editorial: Circadian Rhythm: From Microbes to Hosts. Bellet MM, Eckel-Mahan K, Romani L. Front Cell Infect Microbiol. 2020 Nov 2;10:613181. doi: 10.3389/fcimb.2020.613181. eCollection 2020. PMID: 33224903
Remembering Paolo: A tribute to Paolo Sassone-Corsi. Foulkes NS, Eckel-Mahan K, Cermakian N. J Pineal Res. 2020 Nov;69(4):e12692. doi: 10.1111/jpi.12692. Epub 2020 Sep 19. PMID: 32846002
Circadian Clock and Complement Immune System-Complementary Control of Physiology and Pathology? Shivshankar P, Fekry B, Eckel-Mahan K, Wetsel RA. Front Cell Infect Microbiol. 2020 Aug 14;10:418. doi: 10.3389/fcimb.2020.00418. eCollection 2020. PMID: 32923410
Paraventricular hypothalamus mediates diurnal rhythm of metabolism. Kim ER, Xu Y, Cassidy RM, Lu Y, Yang Y, Tian J, Li DP, Van Drunen R, Ribas-Latre A, Cai ZL, Xue M, Arenkiel BR, Eckel-Mahan K, Xu Y, Tong Q. Nat Commun. 2020 Jul 30;11(1):3794. doi: 10.1038/s41467-020-17578-7. PMID: 32732906
Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K. FASEB J. 2020 Jun;34(6):8265-8282. doi: 10.1096/fj.201903100RR. Epub 2020 Apr 15. PMID: 32294302
HNF4α-Deficient Fatty Liver Provides a Permissive Environment for Sex-Independent Hepatocellular Carcinoma. Fekry B, Ribas-Latre A, Baumgartner C, Mohamed AMT, Kolonin MG, Sladek FM, Younes M, Eckel-Mahan KL. Cancer Res. 2019 Nov 15;79(22):5860-5873. doi: 10.1158/0008-5472.CAN-19-1277. Epub 2019 Oct 1. PMID: 31575546
2018
Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma. Fekry B, Ribas-Latre A, Baumgartner C, Deans JR, Kwok C, Patel P, Fu L, Berdeaux R, Sun K, Kolonin MG, Wang SH, Yoo SH, Sladek FM, Eckel-Mahan K. Nat Commun. 2018 Oct 19;9(1):4349. doi: 10.1038/s41467-018-06648-6. PMID: 30341289
Transient Overexpression of Vascular Endothelial Growth Factor A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System. Zhao Y, Li X, Yang L, Eckel-Mahan K, Tong Q, Gu X, Kolonin MG, Sun K. Mol Cell Biol. 2018 Oct 29;38(22):e00242-18. doi: 10.1128/MCB.00242-18. Print 2018 Nov 15. PMID: 30126894
Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks. Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, Jastroch M, Schneider S, de Mateo S, Cervantes M, Abbondante S, Tognini P, Orozco-Solis R, Kinouchi K, Wang C, Swerdloff R, Nadeef S, Masri S, Magistretti P, Orlando V, Borrelli E, Uhlenhaut NH, Baldi P, Adamski J*, Tschöp MH*, Eckel-Mahan K*, Sassone-Corsi P*. Cell. 2018 Sep 6;174(6):1571-1585.e11. doi: 10.1016/j.cell.2018.08.042. PMID: 30193114
CircadiOmics: circadian omic web portal. Ceglia N, Liu Y, Chen S, Agostinelli F, Eckel-Mahan K, Sassone-Corsi P, Baldi P. Nucleic Acids Res. 2018 Jul 2;46(W1):W157-W162. doi: 10.1093/nar/gky441. PMID: 29912458
Rosiglitazone reverses high fat diet-induced changes in BMAL1 function in muscle, fat, and liver tissue in mice. Ribas-Latre A, Fekry B, Kwok C, Baumgartner C, Shivshankar S, Sun K, Chen Z, Eckel-Mahan K. Int J Obes. 2019 Mar;43(3):567-580. doi: 10.1038/s41366-018-0090-5. Epub 2018 May 24. PMID: 29795456
Central Circadian Clock Regulates Energy Metabolism. Ding G, Gong Y, Eckel-Mahan KL, Sun Z. Adv Exp Med Biol. 2018;1090:79-103. doi: 10.1007/978-981-13-1286-1_5. PMID: 30390286
Clocks and Cholesterol: Co-agonists in Cardiovascular Disease? Fekry B, Eckel-Mahan K. EBioMedicine. 2017 Jun;20:5-6. doi: 10.1016/j.ebiom.2017.05.021. Epub 2017 May 17. PMID: 28529031
Circadian Metabolomics in Time and Space. Dyar KA, Eckel-Mahan KL. Front Neurosci. 2017 Jul 11;11:369. doi: 10.3389/fnins.2017.00369. eCollection 2017. PMID: 28744188
Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P. Cell Metab. 2017 Sep 5;26(3):523-538.e5. doi: 10.1016/j.cmet.2017.08.015. PMID: 28877456
Guidelines for Genome-Scale Analysis of Biological Rhythms. Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. J Biol Rhythms. 2017 Oct;32(5):380-393. doi: 10.1177/0748730417728663. Epub 2017 Nov 3. PMID: 29098954
2017
2016
Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health. Ribas-Latre A, Eckel-Mahan K. Mol Metab. 2016 Jan 14;5(3):133-152. doi: 10.1016/j.molmet.2015.12.006. eCollection 2016 Mar. PMID: 26977390
Hippocampal PER1: a circadian sentinel controlling RSKy activity during memory formation. Yoo SH, Eckel-Mahan K. J Neurochem. 2016 Sep;138(5):650-2. doi: 10.1111/jnc.13727. PMID: 27554418
Gut microbiota directs PPARγ-driven reprogramming of the liver circadian clock by nutritional challenge. Murakami M, Tognini P, Liu Y, Eckel-Mahan KL, Baldi P, Sassone-Corsi P. EMBO Rep. 2016 Sep;17(9):1292-303. doi: 10.15252/embr.201642463. Epub 2016 Jul 14. PMID: 27418314
Comparative Circadian Metabolomics Reveal Differential Effects of Nutritional Challenge in the Serum and Liver. Abbondante S, Eckel-Mahan KL, Ceglia NJ, Baldi P, Sassone-Corsi P. J Biol Chem. 2016 Feb 5;291(6):2812-28. doi: 10.1074/jbc.M115.681130. Epub 2015 Dec 7. PMID: 26644470
2015 AND EARLIER
Eckel-Mahan K. and Sassone-Corsi, P. (2015). Phenotyping Circadian Rhythms in Mice Curr Protoc Mouse Biol. Sep 1;5(3):271-81.
Patel, V. R., Ceglia, N., Zeller, M., Eckel-Mahan, K., Sassone-Corsi, P., & Baldi, P. (2015). The Pervasiveness and Plasticity of Circadian Oscillations: the Coupled Circadian-Oscillators Framework. Bioinformatics. doi: 10.1093/bioinformatics/btv353
Abbondante, S., Eckel-Mahan, K. L., Ceglia, N. J., Baldi, P., & Sassone-Corsi, P. (2015). Comparative Circadian Metabolomics reveal Differential Effects of Nutritional Challenge in the Serum and Liver. J Biol Chem. doi: 10.1074/jbc.M115.681130
Sahar, S., Masubuchi, S., Eckel-Mahan, K., Vollmer, S., Galla, L., Ceglia, N., . . . Sassone-Corsi, P. (2014). Circadian Control of Fatty Acid Elongation by SIRT1-mediated Deacetylation of Acetyl-CoA Synthetase 1. J Biol Chem.
Dyar, K. A., Ciciliot, S., Wright, L. E., Bienso, R. S., Tagliazucchi, G. M., Patel, V. R., . . . Schiaffino, S. (2014). Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock. Mol Metab, 3(1), 29-41.
Eckel-Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solis, R., Ceglia, N. J., Sahar, S., . . . Sassone-Corsi, P. (2013). Reprogramming of the circadian clock by nutritional challenge. Cell, 155(7), 1464-1478.
Baeza-Raja, B., Eckel-Mahan, K., Zhang, L., Vagena, E., Tsigelny, I. F., Sassone-Corsi, P., . . . Akassoglou, K. (2013). p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci, 33(25), 10221-10234. doi: 10.1523/JNEUROSCI.2757-12.2013
Eckel-Mahan, K., & Sassone-Corsi, P. (2013). Metabolism and the circadian clock converge. Physiol Rev, 93(1), 107-135
Masri, S., Patel, V. R., Eckel-Mahan, K. L., Peleg, S., Forne, I., Ladurner, A. G., . . . Sassone-Corsi, P. (2013). Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A, 110(9), 3339-3344
Eckel-Mahan, K. L., Patel, V. R., Mohney, R. P., Vignola, K. S., Baldi, P., & Sassone-Corsi, P. (2012). Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci U S A, 109(14), 5541-5546
Sharpley, M. S., Marciniak, C., Eckel-Mahan, K., McManus, M., Crimi, M., Waymire, K., . . . Wallace, D. C. (2012). Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition. Cell, 151(2), 333-343. doi: 10.1016/j.cell.2012.09.004
Patel, V. R., Eckel-Mahan, K., Sassone-Corsi, P., & Baldi, P. (2012). CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics. Nat Methods, 9(8), 772-773
Phan, T. X., Chan, G. C., Sindreu, C. B., Eckel-Mahan, K. L., & Storm, D. R. (2011). The diurnal oscillation of MAP (mitogen-activated protein) kinase and adenylyl cyclase activities in the hippocampus depends on the suprachiasmatic nucleus. J Neurosci, 31(29), 10640-10647
Masubuchi, S., Gao, T., O'Neill, A., Eckel-Mahan, K., Newton, A. C., & Sassone-Corsi, P. (2010). Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A, 107(4), 1642-1647. doi: 10.1073/pnas.0910292107
Eckel-Mahan, K., & Sassone-Corsi, P. (2010). Blood pressure AsSAuLTed by the circadian clock. Cell Metab, 11(2), 97-99. doi: 10.1016/j.cmet.2010.01.004
Eckel-Mahan, K., & Sassone-Corsi, P. (2009). Metabolism control by the circadian clock and vice versa. Nat Struct Mol Biol, 16(5), 462-467. doi: 10.1038/nsmb.1595
Eckel-Mahan, K. L., Phan, T., Han, S., Wang, H., Chan, G. C., Scheiner, Z. S., & Storm, D. R. (2008). Circadian oscillation of hippocampal MAPK activity and cAMP: implications for memory persistence. Nat Neurosci.
Schedin, P. J., Eckel-Mahan, K. L., McDaniel, S. M., Prescott, J. D., Brodsky, K. S., Tentler, J. J., & Gutierrez-Hartmann, A. (2004). ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. Oncogene, 23(9), 1766-1779
Eckel, K., Tentler JT, Cappetta GJ, Diamond SE, Gutierrez-Hartmann A. (2003). The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. DNA Cell Biol., 22(2), 79-94
(FOR A COMPLETE LIST, SEE: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/49735909/?sort=date&direction=descending)